Survival for babies born with a birth defect—a 'post-code lottery' – Medical Xpress

             Sign in with                 <a href="https://sciencex.com/profile/sm-login-redirect/fb/" class="login-link" referrerpolicy="unsafe-url">                   <svg>                     <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#logo_fb" x="0" y="0" />                   </svg>                 </a>                 <a href="https://sciencex.com/profile/sm-login-redirect/google/" class="login-link" referrerpolicy="unsafe-url">                   <svg>                     <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#logo_google" x="0" y="0" />                   </svg>                 </a>                 <a href="https://sciencex.com/profile/sm-login-redirect/apple/" class="login-link" referrerpolicy="unsafe-url">                   <svg>                     <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#logo_apple" x="0" y="0" />                   </svg>                 </a>               <br>                 <a href="https://sciencex.com/profile/pwdreset/">Forget Password?</a>               <br>                 <a class="font-weight-normal" href="https://sciencex.com/help/account/">Learn more</a>               <br>share this!<br>Share<br>2<br>Share<br>Email<br>                                                         July 13, 2021                                                                                                              <br>                                           by <a class="article-byline__link" href="http://www.kcl.ac.uk/" target="_blank">King's College London</a>                                  <br>Survival for a baby born with a birth defect—otherwise known as a congenital anomaly—is a "post-code lottery", according to scientists from 74 countries.<br>A study published today in <i>The Lancet</i>, led by researchers from King's College London, examined the risk of mortality for nearly 4000 <a href="https://medicalxpress.com/tags/babies/" rel="tag" class="textTag">babies</a> born with <a href="https://medicalxpress.com/tags/birth+defects/" rel="tag" class="textTag">birth defects</a> in 264 hospitals around the world. The study found babies born with birth defects involving the <a href="https://medicalxpress.com/tags/intestinal+tract/" rel="tag" class="textTag">intestinal tract</a> have a two in five chance of dying in a low-income country compared to one in five in a middle-income country and one in twenty in a high-income country.<br>Gastroschisis, a birth defect where the baby is born with their intestines protruding through a hole by the umbilicus has the greatest difference in mortality with 90% of babies dying in low-income countries compared with 1% in high-income countries. In high-income countries, most of these babies will be able to live a full life without disability.<br>Principal Investigator Dr. Naomi Wright is a Paediatric Surgery Registrar from King's College London who has devoted the last four years to studying these disparities in outcome. She said: "Geography should not determine outcomes for babies who have correctable surgical conditions. The Sustainable Development Goal to 'end <a href="https://medicalxpress.com/tags/preventable+deaths/" rel="tag" class="textTag">preventable deaths</a> in newborns and children under 5 years old by 2030' is unachievable without urgent action to improve <a href="https://medicalxpress.com/tags/surgical+care/" rel="tag" class="textTag">surgical care</a> for newborns in low- and <a href="https://medicalxpress.com/tags/middle-income+countries/" rel="tag" class="textTag">middle-income countries</a>."<br>Mr Andrew Leather, co-author and Director of the King's Centre for Global Health and Health Partnerships at King's College London said: "There needs to be a focus on improving surgical care for newborns in low- and middle-income countries globally. Over the last 25 years, while there has been great success in reducing deaths in children under 5 years by preventing and treating infectious diseases, there has been little focus on improving surgical care for babies and children and indeed the proportion of deaths related to surgical diseases continues to rise.<br>"Birth defects are now the 5th leading cause of death in children under 5 years of age globally, with most deaths occurring in the newborn period. Birth defects involving the intestinal tract have a particularly high mortality in low- and middle-income countries as many are not compatible with life without emergency surgical care after birth."<br>In high-income countries, most women receive an antenatal ultrasound scan to assess for birth defects. If identified, this enables the woman to give <a href="https://medicalxpress.com/tags/birth/" rel="tag" class="textTag">birth</a> in a hospital with children's surgical care so the baby can receive help as soon as it is born. In low- and middle- income countries, babies with these conditions often arrive late to the children's surgical centre in a poor clinical condition. The study shows that babies who present to the children's surgical centre already septic with infection have a higher chance of dying.<br>Co-author Mr Niyi Ade-Ajayi, Paediatric Surgeon at King's College Hospital and Co-Chair of the International Affairs Committee of the British Association of Paediatric Surgeons added: "The study highlights the importance of perioperative care (the care received either side of the corrective operation or procedure) at the children's surgical centre. Babies treated at hospitals without access to ventilation and intravenous nutrition when needed had a higher chance of dying. Furthermore, not having skilled anaesthetic support and not using a surgical safety checklist at the time of operation were associated with a higher chance of death."<br>The team of researchers found that improving survival from these conditions in low- and middle-income countries involves three key elements:<br>1) improving antenatal diagnosis and delivery at a hospital with children's surgical care,<br>2) improving surgical care for babies born in district hospitals, with safe and quick transfer to the children's surgical centre,<br>3) improved perioperative care for babies at the children's surgical centre.<br>They acknowledge that this requires strong teamwork and planning between midwifery and obstetric teams, newborn and paediatric teams, and children's surgical teams at the children's surgical centre, alongside outreach education and networking with referring hospitals.<br>They also urge that alongside local initiatives, surgical care for babies and <a href="https://medicalxpress.com/tags/children/" rel="tag" class="textTag">children</a> needs to be integrated into national and international child health policy and should no longer be neglected within global child health.<br><strong>More information:</strong>                                                     Naomi Jane Wright et al, Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study, <i>The Lancet</i> (2021). DOI: 10.1016/S0140-6736(21)00767-4                                                                                                                                                                                               <div class="mt-3">                                                  <strong>Journal information:</strong>                                                                                                           <a href="https://medicalxpress.com/journals/lancet/"><cite>The Lancet</cite></a>                                                        <a class="icon_open" href="http://www.thelancet.com/journals/lancet/issue/current" target="_blank" rel="nofollow">                                                          <svg>                                                               <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_open" x="0" y="0"/>                                                            </svg>                                                      </a>                                                                                                    </div>                                                                                          <br>Explore further<br>Facebook<br>Twitter<br>Email<br> Feedback to editors<br>Oct 9, 2025<br><span>0</span><br>Oct 9, 2025<br><span>0</span><br>Oct 8, 2025<br><span>0</span><br>Oct 7, 2025<br><span>0</span><br>Oct 7, 2025<br><span>0</span><br>2 hours ago<br>2 hours ago<br>7 hours ago<br>18 hours ago<br>23 hours ago<br>Oct 10, 2025<br>Oct 10, 2025<br>Oct 10, 2025<br>Oct 10, 2025<br>Oct 10, 2025<br>May 26, 2021<br>Jan 21, 2021<br>Dec 10, 2019<br>Dec 12, 2016<br>Nov 23, 2020<br>Feb 21, 2018<br>Oct 10, 2025<br>Oct 9, 2025<br>Oct 8, 2025<br>Oct 8, 2025<br>Oct 8, 2025<br>Oct 8, 2025<br><br>                                 <small>                                 This summary was automatically generated using LLM.                                  <a class="text-info" href="https://sciencex.com/help/ai-disclaimer/" target="_blank">Full disclaimer</a>                                 </small>                             <br>                                          Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page.                                            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