Author: 1to90

                                                                                <a href="https://wtop.com/author/alan-etter/">                                                       Alan Etter                                                          </a>                                                                                        <span> | <a href="mailto:alan.etter@wtop.com">alan.etter@wtop.com</a></span>                                                                                                                                <br>October 13, 2025, 6:17 PM<br>Relisha Rudd, an 8-year-old girl who went missing in D.C. in 2014, is the subject of a new docuseries by the national nonprofit organization Black and Missing.<br>The trailer for the upcoming docuseries shows Rudd in a home movie spelling her name for her grandmother. Rudd, smiling with a missing front tooth, would vanish not long after the movie was made.<br><a href="https://blackandmissinginc.com/" target="_blank" rel="noopener">Black and Missing</a> is hoping the docuseries will generate new leads for police. The group raises awareness for missing people of color by creating public awareness campaigns, providing resources and tools to families and educating the community on personal safety.<br>&#8220;We know that by bringing awareness to Relisha&#8217;s case, we can bring about answers as to what happened to her,&#8221; Black and Missing co-founder Natalie Wilson told WTOP. &#8220;We will never stop searching for her.&#8221;<br>Rudd was a second grader at Payne Elementary School when she went missing March 1, 2014. She was last seen on surveillance video at the Holiday Inn Express motel in the company of Kahlil Tatum, a janitor for a D.C. General Family Shelter where Rudd had been living with her mother, Shamika Young.<br>The motel in Northeast was known for criminal activities, including drug use and prostitution.  <div class="Widget WidgetList WidgetRelatedStories alignleft">             <h3 class="Widget-title widget-title-related-stories">          Related stories     </h3>       <ul class="Widget-list">            <li class="Widget-item">            <a class="Widget-itemLink" href="https://wtop.com/dc/2024/03/somebody-out-there-knows-something-search-continues-for-dc-girl-who-went-missing-10-years-ago/">               <strong class="Widget-itemTitle">&#8216;Somebody out there knows something&#8217;: Search continues for DC girl who went missing 10 years ago</strong>                      </a>        </li>           <li class="Widget-item">            <a class="Widget-itemLink" href="https://wtop.com/dc/2022/03/community-members-gather-to-remember-relisha-rudd-and-ask-for-help-solving-her-disappearance/">               <strong class="Widget-itemTitle">Community members gather to remember Relisha Rudd and ask for help solving her disappearance</strong>                      </a>        </li>           <li class="Widget-item">            <a class="Widget-itemLink" href="https://wtop.com/dc/2020/03/six-years-after-she-went-missing-gather-to-spur-tips-that-lead-to-a-dc-girl/">               <strong class="Widget-itemTitle">DC locals still seeking answers on 6-year anniversary of Relisha Rudd&#8217;s disappearance</strong>                       </a>        </li>       </ul> </div><br>A month after Rudd was last seen, Tatum was found dead in a shed in Kenilworth Park in an apparent suicide.<br>Though more than 11 years have passed, Wilson hopes the film will spark new interest in the investigation.<br>&#8220;She&#8217;s really D.C.&#8217;s baby that&#8217;s missing. We want to know what happened to Relisha,&#8221; Wilson said. &#8220;The community deserves to know what happened to Relisha, and it takes all of us — that&#8217;s the media, law enforcement, but most importantly our community — to get involved to help find and bring our missing home.&#8221;<br>Officially, Rudd&#8217;s disappearance is unsolved, but police continue to ask the public for information about the case. The FBI is offering a $25,000 reward for information.<br>The two-part docuseries will be released on Oct. 29, Rudd&#8217;s 20th birthday.<br><em style="font-size: 16px; font-weight: 600;">Get breaking news and daily headlines delivered to your email inbox by signing up <a href="https://wtop.com/newsletter-signup/" target="_blank" rel="noopener">here</a>.</em><br>© 2025 WTOP. All Rights Reserved. This website is not intended for users located within the European Economic Area.<br>5425 Wisconsin Ave<br />                 Chevy Chase, MD 20815<br>                     <a href="mailto:hello@wtop.com">hello@wtop.com</a>                 <br>                     <a href="tel:2028955000">202.895.5000</a>                 <br><br>Copyright © 2025 by WTOP. All rights reserved. This website is not intended for users located within the European Economic Area.<br><br><a href="https://news.google.com/rss/articles/CBMixgFBVV95cUxOcGdkNld2czVsQUQwNUFVNkdDcTVGczBpQ1liLTFzcnpCT0NwbVZvemRRMEJERjNhdFdINlJNWnJ3ZEo4aEV5RmZlQ2lQYnhld2lqTE5lWndKTEdTWXZDYzdKLTBYYXNwRklTNXJVQnBRVkVMMHFla0Z6bnA0TGhNZUQtc2xGckpJYmpUZm5iX1ZTZ2lZRzFnellxQlB2Z05OcjJvMUFEaDBvd0xKQ1ZzQzZ5TWhQTXpOODdwZkMxWHBlMlZtbkE?oc=5">source</a>

THE National Lottery Set For Life numbers are in and it's time to find out if you've won the top prize of £10,000 every month for 30 years.
Could tonight's jackpot see you start ticking off that bucket list every month or building your own start-up as a budding entrepreneur?
You can find out by checking your ticket against tonight's numbers below.
Good luck!
The winning Set For Life numbers are: 04, 24, 27, 31, 36 and the Life Ball is 08.
The first National Lottery draw was held on November 19 1994 when seven winners shared a jackpot of £5,874,778.
The largest amount ever to be won by a single ticket holder was £42million, won in 1996.
Gareth Bull, a 49-year-old builder, won £41million in November, 2020 and ended up knocking down his bungalow to make way for a luxury manor house with a pool.
Sue Davies, 64, bought a lottery ticket to celebrate ending five months of shielding during the pandemic — and won £500,000.
Sandra Devine, 36, accidentally won £300k – she intended to buy her usual £100 National Lottery Scratchcard, but came home with a much bigger prize.
The biggest jackpot ever to be up for grabs was £66million in January last year, which was won by two lucky ticket holders.
Another winner, Karl managed to bag £11million aged just 23 in 1996.
The odds of winning the lottery are estimated to be about one in 14million – BUT you've got to be in it to win it.
©News Group Newspapers Limited in England No. 679215 Registered office: 1 London Bridge Street, London, SE1 9GF. “The Sun”, “Sun”, “Sun Online” are registered trademarks or trade names of News Group Newspapers Limited. This service is provided on News Group Newspapers’ Limited’s Standard Terms and Conditions in accordance with our Privacy & Cookie Policy. To inquire about a licence to reproduce material, visit our Syndication site. View our online Press Pack. For other inquiries, Contact Us. To see all content on The Sun, please use the Site Map. The Sun website is regulated by the Independent Press Standards Organisation (IPSO)
Our journalists strive for accuracy but on occasion we make mistakes. For further details of our complaints policy and to make a complaint please click this link: thesun.co.uk/editorial-complaints/

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The GIST: To help you make your picks, a deep dive into the men’s basketball (MBB) and women’s basketball (WBB) March Madness brackets will hit your inbox tomorrow and Wednesday, respectively, but in the meantime, let’s break down some Selection Sunday stats.
Zero: The number of people more hyped than Texas’ women when they received their No. 1 seed. Pro tip: Turn down your volume before clicking that link.
3: The number of 2023 Final Four teams (No. 1 UConn, No. 5 San Diego State, and No. 8 FAU) in the men’s East region, which is likely the toughest path to the Final Four across both brackets. Even more intimidating? That quadrant also includes four freshly-minted conference tournament champions (UConn, No. 2 Iowa State, No. 3 Illinois, and No. 4 Auburn). Cutthroat doesn’t cover it.
6: The teams dancing for the first time. Conference tournament champions No. 15 Cal Baptist WBB, No. 16 Texas A&M-Corpus Christi WBB, and No. 16 Stetson MBB are on to the first round, while No. 16 Presbyterian WBB and No. 16 Grambling State MBB will duke it out in “First Four” games this week.
8: The most teams any conference is sending to March Madness. On the women’s side, the ACC and SEC have the most contenders, while the Big 12 and SEC each added eight in the men’s bracket.
10: How many mid-major teams scooped up at-large tickets. Eight men’s teams earned this distinction, while just No. 4 Gonzaga and the aforementioned Columbia made the women’s bracket without bringing home conference hardware first.
22: The number of schools sending their women and men to the Big Dance. Get you a team that can do both.
6:40 p.m. ET: The time when this year’s edition of the best tournament in sports officially tips off — Wagner and Howard MBB will fight for a No. 16 seed in a First Four bout tomorrow. LFG.
Sign up for The GIST and receive the latest sports news straight to your inbox three times a week.

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It Happened Again: Expected Catalyst Triggers Bitcoin’s Bearish Cycle (BTC-USD)  Seeking Alpha
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1. Small Plane Crashes on Massachusetts Highway, Killing 2  The New York Times
2. Middletown couple killed in small plane crash on I-195 in Dartmouth  WJAR
3. Married Rhode Island couple identified as victims of Mass. plane crash  WCVB
4. Plane crashes onto a Massachusetts highway, killing 2 and wounding 1 on the ground  ABC News – Breaking News, Latest News and Videos
5. Small plane crash on I-195 in Dartmouth kills husband and wife from RI. Live updates  SouthCoastToday.com

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Ripple Is Offering $200K to 'Attack' XRP Ledger Lending Protocol
$115,726.00
$4,263.79
$1,282.20
$2.62
$208.17
$0.9999
$4,266.28
$0.216068
$0.323961
$0.731811
$5,194.28
$4,591.41
$115,852.00
$20.11
$0.998454
$1.001
$42.74
$4,609.83
$0.352687
$547.39
$2.99
$23.80
$4,275.03
$1.001
$9.68
$0.193596
$1.00
$115,762.00
$100.09
$1.001
$2.13
$0.00001126
$43.72
$0.173329
$2.37
$316.02
$1.20
$3.42
$7.10
$260.76
$436.93
$0.149765
$260.94
$187.90
$2.05
$4.95
$0.00000792
$0.46343
$2.65
$257.31
$1.46
$1.00
$3.94
$1.00
$17.60
$0.838033
$4,269.31
$1.072
$1.00
$1.00
$1.016
$5.69
$6.94
$0.210811
$223.15
$0.997814
$3.75
$16.60
$0.00000207
$0.359999
$4,877.48
$14.55
$0.213682
$1.001
$0.221672
$4,511.43
$0.03471213
$0.02017677
$0.064798
$3.64
$1,283.80
$1.001
$42.72
$0.02647275
$4,504.90
$3.05
$0.02056842
$4,124.46
$4,612.06
$0.065157
$0.00429685
$0.238277
$115,700.00
$4,528.58
$92.47
$6.59
$0.00001689
$0.400301
$4,127.23
$1.34
$3.64
$1.24
$6.14
$1.73
$0.621048
$115,277.00
$1.00
$1.13
$0.999708
$0.061166
$4,587.92
$238.06
$1.98
$0.286829
$1.21
$0.375452
$9.99
$115,932.00
$1.019
$0.508066
$116,648.00
$0.492051
$0.628028
$277.18
$2.02
$2,398.72
$0.948781
$1.00
$0.455439
$0.215374
$4,076.94
$2.30
$112.92
$0.073902
$0.13388
$1.00
$0.00007831
$4,270.44
$10.85
$0.659384
$0.04885466
$115,515.00
$0.118522
$0.260287
$0.998397
$1.092
$1.29
$0.162679
$4,579.50
$3.87
$4,274.00
$4,269.13
$0.124258
$51.22
$0.00766261
$3.26
$0.606971
$0.604672
$1.036
$1.44
$0.079471
$17.77
$4,591.26
$0.01259302
$2.16
$4,695.55
$0.13295
$0.875546
$0.234487
$4,696.12
$0.575048
$0.21686
$0.01142361
$0.998162
$0.286211
$115,788.00
$1.41
$0.00000054
$1,354.17
$0.329283
$4,598.96
$1.002
$2.33
$0.306703
$1.001
$1.10
$1.24
$0.479762
$0.02497916
$23.68
$0.9999
$1.001
$0.99991
$4,708.96
$4,265.17
$4,224.76
$0.454213
$29.18
$0.40097
$42.70
$5.74
$4,265.22
$2.30
$0.088381
$0.179533
$0.093506
$0.00000042
$1.10
$0.411711
$0.448107
$0.0042513
$0.998437
$1.051
$0.12001
$5.59
$23.80
$0.00418518
$0.01277084
$231.02
$4,506.05
$115,865.00
$1.17
$1.098
$0.00613666
$1.20
$0.03676477
$140.04
$1.00
$42.85
$0.244854
$6.29
$0.459632
$21.72
$5,208.92
$239.34
$0.03546009
$4,266.04
$36.18
$0.00989888
$0.00679782
$0.00081676
$0.351935
$0.956283
$19.69
$114,724.00
$0.02122326
$0.00000156
$0.00001641
Ripple is offering up to $200,000 to users who find security flaws in the proposed XRP Ledger lending protocol, incentivizing white hat hackers to “attack” the upcoming platform.
The rewards are part of an “attackathon” hosted by Ripple and blockchain security firm Immunefi that asks security researchers to poke and prod the codebase to find potential flaws, with a particular focus given to bugs that impact fund security and vault solvency. 
"The XRPL community is preparing for one of its most significant upgrades yet with the proposed lending protocol, which is expected to go to validator vote later this year. Before any major amendment like this moves forward, it’s critical to ensure the code is as secure and resilient as possible," RippleX Head of Product Jasmine Cooper told Decrypt. 
"Partnering with Immunefi, one of the top on-chain security platforms, allows us to tap into a global network of elite researchers who have secured some of the largest DeFi protocols to date," she added. "The Attackathon is just one part of a broader, layered security process."
To encourage those without experience on XRP Ledger, the firms are opening a two-week educational period for interested participants. During this time, researchers can gain support from Ripple engineers, access devnet guides and test environments, and more. 
After the education period is over, the attackathon will begin on October 27 and run through November 29. 
“If even one valid bug is found during the program, the full $200,000 is unlocked and will be distributed,” the announcement post reads. “If no bugs are found, a fallback pool of $30,000 is paid out to participants who submitted valid insights.”
The XRP Ledger lending protocol was introduced last fall at XRP Ledger Apex, a Ripple-hosted summit dedicated to fostering the build of the decentralized network. 
The protocol aims to introduce fixed-term, uncollateralized loans directly on XRP Ledger, without using smart contracts or wrapped assets. Instead, the protocol deliberately will rely on off-chain procedures to determine creditworthiness. Funds will then be pooled on-chain and repayments follow protocol-enforced terms.
Specific targets for the attackathon participants include liquidation logic, interest accrual bugs that may reward the wrong party, administrative attacks that could allow for alteration of protocol records, among others. 
While payments firm Ripple is linked to the network’s native token XRP and is a major contributor to the XRP Ledger, it does not have an affiliation with the bulk of the XRP Ledger validators. In August, former Ripple CTO David Schwartz told Decrypt that the firm runs “something like 1% of the XRP Ledger.” 
The network earned a last place security ranking from research firm Kaiko when compared to 14 other blockchains in August. But developers for the ledger pushed back on the claim and highlighted security endorsements from firms like CertiK, Halborn, and FYEO.
Your gateway into the world of Web3
The latest news, articles, and resources, sent to your inbox weekly.
© A next-generation media company. 2025 Decrypt Media, Inc.

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In 31 years of marriage, Cheryl Bach and her husband never took their honeymoon, but a scratch-off lottery ticket changed those plans.
Bach won $1 million from the $10 Million Spectacular game after buying a ticket from Harris Teeter on Village Walk Drive in Holly Springs. Bach said she couldn’t believe her eyes when she won.
Other WRAL Top Stories
“I had to put my glasses on to make sure I was seeing it right,” Bach said. “I was shaking for the rest of the day.”
After taking some time to calm down, Bach said the first person she told was her husband.
“He didn’t believe me,” Bach said. “I had to take a picture and show him.”
Bach claimed her prize on Friday at the lottery headquarters, choosing to receive the prize as a $600,000 lump sum. After state and federal tax withholdings, she took home $430,514.
In addition to her honeymoon, Bach said she plans to use the rest of the winnings to pay some bills.
The $10 Million Spectacular game debuted in December 2023 with five top prizes of $10 million, 20 prizes of $1 million and 20 prizes of $100,000. Since the last $10 million prize has been claimed, the lottery has started the process of ending the game.

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Mass photometry (MP) is rapidly transforming the landscape of biomolecular analysis, providing a novel and potent method for investigating the complex interplay of molecular structure, dynamics, and interactions in biological systems. By leveraging the intricate physics associated with light and matter, MP facilitates the observation and quantification of biomolecules at the single-molecule level, unraveling the intricacies underpinning biological functions. This technique allows researchers to explore the quaternary structures of biomolecules, opening new avenues in our understanding of biochemistry and cellular biology.
At the heart of mass photometry lies the ability to detect and measure the optical contrast that individual molecules generate when positioned at a glass-water interface. This unique characteristic is fundamental for achieving mass-resolved quantification of complex biomolecular mixtures, which can include proteins, nucleic acids, and lipids among others. Essentially, the MP technique relies on detecting differences in light scattering that occur when molecules interact with a surface, enabling researchers to deduce mass information for single molecules within a given sample.
Despite the promising potential of mass photometry, real-world applications of this technology are often subject to challenges that can hinder performance. Ideally, the accuracy of MP measurements should only be affected by photon shot noise, the statistical fluctuations arising from the discrete nature of light. However, various factors play a significant role in determining the efficacy of mass photometry, including the properties of the sample, the interface used, and the technical parameters of the measurement process. It is thus imperative for researchers to understand these parameters to maximize the technique’s effectiveness.
One crucial aspect influencing the performance of mass photometry is the characteristics of the molecular sample being analyzed. The concentration of analytes, the presence of contaminants, the molecular size, and the overall composition of the sample can significantly affect measurement outcomes. Therefore, careful preparation of samples is essential to obtain reliable and reproducible results. Researchers must consider the intricacies of biomolecular behavior and strive to optimize conditions prior to conducting MP analyses.
Another key parameter in achieving optimal mass photometry outcomes is ensuring that the optical interface, typically a glass surface, is properly prepared for measurements. Surface treatments such as amination can enhance the properties of the glass for improved interaction with biological samples. While this process can add roughly two hours to the preparation time, it can markedly improve measurement sensitivity and accuracy. It is crucial for researchers to weigh the benefits of surface treatment against time constraints and the specific requirements of their experiments.
The speed at which mass photometry can analyze samples is one of its most appealing characteristics. With a typical analysis time of less than ten minutes per sample, researchers can obtain rapid insights into biomolecular interactions and structures. This efficiency allows for higher throughput in experiments, making MP a highly valuable tool in both academic and industrial research settings. Researchers can harness the speed of MP to conduct dynamic studies of biomolecular behavior and gather more comprehensive data sets within minimal time frames.
Improvement in sensitivity and quantitative detection limits can also be realized through meticulous optimization of experimental variables in mass photometry. Factors such as buffer composition, sample handling, and measurement parameters can greatly influence the sensitivity of the technique. For instance, using a buffer that minimizes background noise while facilitating optimal optical conditions can provide clearer signals and enhance the overall accuracy of results.
Another critical consideration for achieving optimal results in mass photometry is the reproducibility of measurements. The technique demands precision, and any variability in experimental conditions or sample preparation can lead to discrepancies in outcomes. Researchers must adopt stringent protocols for sample preparation and measurement procedures to reduce variability and enhance reproducibility. Standardizing these procedures across different experiments will also allow for better comparison of results, enabling more robust conclusions to be drawn from the data.
In addition to optimizing experimental conditions, advancing the computational frameworks used to analyze mass photometry data is essential. With the increasing complexity of biomolecular interactions, the need for sophisticated algorithms capable of deconvoluting overlapping signals becomes increasingly pertinent. Researchers must invest in developing and refining computational methods to enhance the extraction of meaningful information from mass photometry datasets, which can assist in discerning the subtle nuances of molecular interactions.
One of the remarkable features of mass photometry is its versatility in studying a wide array of biomolecular interactions. From discerning the binding affinities between proteins to investigating the dynamics of nucleic acid complexes, MP can cover a broad spectrum of biological questions. This capacity to study multiple types of biomolecular entities makes it an indispensable resource in modern biochemical research, paving the way for advances in therapeutic design, drug discovery, and foundational biological understanding.
Furthermore, as mass photometry continues to evolve, researchers are exploring its integration with other analytical techniques, potentially increasing its power and applicability. Combining MP with additional methods such as fluorescence microscopy or ion mobility spectrometry could provide multidimensional insights into biomolecular behavior and interactions, enhancing our understanding of complex biological systems. The synergy between different techniques can usher in new methodologies that allow for more comprehensive investigations of biomolecular phenomena.
In summary, mass photometry represents a groundbreaking advancement in the study of biomolecular structure and interactions. Its ability to provide real-time, single-molecule measurements in an efficient and accessible manner positions it as a forefront technique in modern scientific research. As researchers continue to refine this methodology and address the challenges associated with its application, there lies tremendous potential for mass photometry to unravel the complexities of biological systems. The continued development of best practices and optimization methods will undoubtedly enhance the utility and accuracy of this technique, empowering scientists to explore new frontiers in biomolecular analysis.
In conclusion, while mass photometry has already made significant strides, the ongoing refinement of this technique will be crucial for unlocking further insights into the life sciences. By employing best practices and remaining vigilant about the factors influencing measurements, researchers can fully harness the potential of mass photometry as a powerful analytical tool. As studies continually reveal the intricate details of biomolecular interactions, mass photometry stands as a testament to the evolving nature of scientific exploration.
Subject of Research: Mass Photometry and Biomolecular Analysis
Article Title: Best practice mass photometry: a guide to optimal single-molecule mass measurement
Article References:
Kratochvíl, J., van Wee, R., Thiele, J.C. et al. Best practice mass photometry: a guide to optimal single-molecule mass measurement.
Nat Protoc (2025). https://doi.org/10.1038/s41596-025-01255-4
Image Credits: AI Generated
DOI: 10.1038/s41596-025-01255-4
Keywords: mass photometry, biomolecular structure, single-molecule analysis, optical contrast, quantitative detection, sensitivity, reproducibility
Tags: advancements in cellular biology techniquesanalyzing complex biomolecular mixturesbiomolecular interactions measurementchallenges in mass photometry applicationslight scattering in biomolecular studiesmass photometry techniquesmass-resolved quantification methodsoptical contrast in mass photometryphoton shot noise in scientific measurementsprecision in biomolecular quantificationquaternary structures of biomoleculessingle-molecule analysis in biochemistry
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Checkmate is a Bitcoin analyst known for his on-chain & macro research. In this episode, we get into the weekend’s deleveraging event across the markets, the structural fragility it exposed, and why Bitcoin’s resilience through it all might mark a new era of maturity for the asset.
Checkmate breaks down what caused over $20 billion in liquidations, how cascading leverage turned minor sell-offs into total wipeouts, and why market makers simply “walked away.” He also explains why Bitcoin’s fundamentals, ETF inflows, spot demand, and deep capital pools make it better positioned than ever despite short-term volatility. We discuss how Bitcoin is becoming the world’s 24/7 macro signal, why “crypto” may be entering terminal decline, and what the data says about sentiment, and the critical price levels that will determine whether this was just a reset, or the start of a broader bear market.
In this episode:
– The $20 billion liquidation and what triggered it
– How leverage cascades break market sentiment
– Bitcoin’s structural strength
– Why Bitcoin is the world’s macro thermometer
Listen: Spotify • Apple Podcasts • Fountain
Watch: YouTube

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