Market Volatility Grows as Bay Miner Next-Gen App’s USD-Pegged Contracts Secure ETH and XRP Earnings
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Let PharmaVoice's free newsletter keep you informed on what industry leaders are saying, straight from your inbox. <br><br>Partnerships have been key to building the company’s AI capabilities and patient-focused R&D, said AstraZeneca’s head of U.S. oncology.<br>Among the strategies Big Pharma is employing to achieve more equitable health outcomes, AI is now playing a larger role. For AstraZeneca, a series of AI-based partnerships and screening initiatives is setting the stage to gather and use data for cancer patients in neglected ZIP codes.<br>As it stands, innovation is outpacing health equity, widening the gap in oncology between patients who have access to novel medicines and those who do not, said AstraZeneca’s senior vice president and head of U.S. oncology Mohit Manrao.<br>Black Americans have <a href="https://www.cancer.gov/about-cancer/understanding/disparities">higher death rates</a> than any other racial group for many cancer types, according to the NIH’s National Cancer Institute. Furthermore, people without access to healthcare are more likely to be diagnosed later in their disease trajectory, putting them at greater risk of death.<br>“Science is moving so fast, but the job isn’t done after that,” Manrao said. “The challenge we have at a local level is that disparities are increasing, and more and more people fall through the cracks. Everyone in the system has good intent, but it’s important that as an industry, we embrace opportunities and collaborate to solve for it.”<br>AI is one of the most promising opportunities for improved health equity, Manrao said. By teaming up with diagnostic makers and AI companies, AstraZeneca wants to use data to expose the disparities in care, and address screening and access issues that exacerbate them. Manrao said AstraZeneca’s mission goes beyond developing oncology meds like the blockbuster Enhertu, which was originally approved for breast cancer in 2019 and <a href="https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-enhertu-her2-positive-solid-tumors">recently scored a new expanded indication</a>, and AI can find patients who need it.<br>"The secret sauce for us, and it’s not truly secret, is external collaboration. What stands out for us and for anybody who wants to move the needle for patients is that we can’t work in silos."<br>Mohit Manrao<br>Head of U.S. oncology, AstraZeneca<br>“There is no reason that a Black woman with breast cancer in New York should have different outcomes than a white woman living in California or Atlanta — the ZIP code lottery exists today,” Manrao said.<br>Here, Manrao discusses the effect data-driven AI can have on the understanding and mitigating disparities in cancer care, the partnerships AstraZeneca has sought to bring AI into the fold, and how the feedback loop will also help drive better R&D for more equitable outcomes down the road.<br><em>This interview has been edited for brevity and style.</em><br><strong>MOHIT MANRAO:</strong> Availability of data has multiplied in a multitude of ways, both in terms of genomic data and multi-omics data at a patient level and a customer engagement level. Similarly, science, technology and data are converging very quickly, and that helps us believe we can have an impact on patients at every level. From a health equity lens, beyond our bread and butter in biopharmaceutical innovation, we want to start looking at the entire patient pathway and ask new questions. Are patients getting screened? What are the risk factors? Are they going to screening centers? Are they followed up appropriately in the system at the right intervals to be detected early?<br>Because of the socio-economic determinants of health, we need to have individualized interventions to solve for specific barriers that get in the way of a specific patient.<br>It’s a super important point. Being aware of bias that would get into a system and putting checks and balances around it can help us look at health equity. Across the pharmaceutical value chain, it starts with inclusive R&D. We have drugs that get developed based on biosamples, and we’re working on creating diverse biosamples that are representative of the populations we serve. Of course, we can’t do that alone. So working at a local grassroots and community level to bring those diverse biosamples into drug development helps ensure that patient recruitment meets those goals. <br>For instance, at a clinical trial centered in a community in New Jersey that is 18% Black, we work with them to ensure that not only 18% is recruited from that community, but more so that we can help dig and gather data. And all this serves to help AI predict without bias.<br>When ChatGPT came out, it exploded into the world in a visible way, but we have been using AI in different parts of the value chain already. We have more than 700 data scientists who are AI experts working in different parts of our organization from early drug discovery to development to commercial organizations and operations. We’ve embedded them to think in terms of looking for partnerships — we can’t move forward alone. So looking at the right partners with the capabilities, values and vision in terms of transforming cancer care is very critical. For example, in early detection, there are a multitude of challenges. If we see that tissue-based screening is a challenge, we work with blood-based companies to look at how we can help improve their assay. That led us to <a href="https://grail.com/press-releases/grail-announces-strategic-collaboration-with-astrazeneca-to-develop-companion-diagnostic-tests-to-enable-the-treatment-of-early-stage-cancer/">work with Grail</a> in that space. <br><a href="http://qure.ai">Companies like Qure.ai</a> can use technology to find lung nodules on X-rays that a naked eye couldn’t see, and <a href="https://www.clinithink.com/news/clinithink-and-astrazeneca-launch-first-of-its-kind-ai-project-aimed-at-detecting-early-stage-lung-cancer#:~:text=Clinithink%2C%20the%20company%20that%20has,treatment%20can%20be%20more%20effective.">companies like Clinithink</a> have natural language processing that can go into electronic medical records. These are all important steps.<br>At the same time, let’s take the example of lung cancer — screening has been approved in the U.S. since 2013 and even a decade later, the uptake is dismal at only 5% to 6%. Socio-economic determinants are a barrier to lung cancer screening, and we’ve worked with the Association of Cancer Care Centers to understand and work with local communities, and use that rich data to inform where the pockets are, such as a <a href="https://www.accc-cancer.org/projects/appalachian-community-cancer-alliance/appalachian-community-cancer-alliance">rural Appalachian screening program</a> for lung cancer in Kentucky. <br>Similarly, we just announced a partnership with the University of Maryland system across counties in the state to identify at-risk populations. These academic and community institutes play a big part in the data-gathering process.<br>It’s critical that we put patients at the heart of drug discovery and development. All this data, in many ways, unlocks opportunities to uncover true unmet needs for patients, and the bigger picture is we want to eliminate cancer as a cause of death. Understanding through these datasets why the disease is progressing and informing R&D by identifying patients earlier. The partnership with Grail, for instance, helps us not only identify patients but also to look at the data and [see] which patients within this group are high-risk and the kinds of interventions they need. So this is integrated across the internal value chain.<br>The secret sauce for us, and it’s not truly secret, is external collaboration. We don’t shy away from partnering with the right party. What stands out for us and for anybody who wants to move the needle for patients is that we can’t work in silos.<br>Get the free daily newsletter read by industry leaders<br>The race is on for an insulin-producing treatment that doesn’t require immune suppressing drugs.<br>Keep up with the story. Subscribe to the PharmaVoice free daily newsletter<br>Subscribe to PharmaVoice for important stories, insights & perspectives<br>Get the free daily newsletter read by industry leaders<br>The race is on for an insulin-producing treatment that doesn’t require immune suppressing drugs.<br>The free newsletter covering the top industry headlines<br><br><a href="https://news.google.com/rss/articles/CBMilgFBVV95cUxPU3JBcnV3VDhzbUtRSkNxcDN4eE1SZDZLZk5HMUVneFlRMmdpUFdVbFdUOTBfVGVfNGRyUUduZURYN0phTmZpMWwwR1dWOUxpZEZURGQyaF9FYVkya2s2TldvU3p5cHY3RHdrTDBqc19CN09ZdEo3Vll0SGdhZUcwNUJwVUdLZ2xNbEo1eGxFWlRoWW5RWXc?oc=5">source</a>
ChainCatcher news indicates that according to SoSoValue data, after statements from Trump and Vance, China-U.S. relations have somewhat eased, leading to a release of market panic. The cryptocurrency sector has rebounded across the board, with a general increase of about 6% to 20% over 24 hours. Among them, the Layer2 sector led with a rise of 19.40%, where Mantle (MNT) surged by 38.30%, and Celestia (TIA) and Zora (ZORA) increased by 15.04% and 25.26%, respectively. Additionally, Bitcoin (BTC) rose by 4.85%, breaking through $115,000, while Ethereum (ETH) increased by 11.66%, climbing above $4,100.
It is worth mentioning that MAG7.ssi rose by 9.69%, DEFI.ssi increased by 12.32%, and MEME.ssi went up by 9.58%.
Other standout sectors include: the AI sector, which rose by 16.50% over 24 hours, with Bittensor (TAO) increasing by 37.75%; the CeFi sector, which rose by 15.36%, with Binance Coin (BNB) increasing by 16.87%; the Layer1 sector, which rose by 12.80%, with Solana (SOL) and Cardano (ADA) increasing by 12.75% and 13.69%, respectively; and the DeFi sector, which rose by 12.55%, with World Liberty Financial (WLFI) increasing by 18.67%.
In other sectors, the Meme sector rose by 12.04%, with SPX6900 (SPX) increasing by 22.98%; the PayFi sector rose by 8.17%, with Dash (DASH) surging by 50.55%.
The cryptocurrency sector indices reflecting historical performance show that the ssiLayer2, ssiAI, and ssiCeFi indices rose by 21.21%, 19.56%, and 16.44%, respectively.
XRP is currently trading at $2.41 after experiencing a brief but severe market crash yesterday. The token has gained 347.06% since January 2025.
During the crash, XRP fell nearly 70% in eight minutes, dropping from $2.65 to $0.78. Bitcoin and Ethereum declined 13% and 15% respectively during the same period.
Market analyst Egrag Crypto suggested the drop was designed to liquidate over-leveraged positions. Large short positions were reportedly opened hours before the event.
🚨 #XRP and Crypto Update 🚨 (1/2):
▫️The recent crash was designed to liquidate all #XRP long positions, and I’m here to explain why and how with proofs.
▫️I’ve received many messages in my DMs, so I want to clarify what happened. While I usually focus on predicting the… pic.twitter.com/f7hUvY37IX
— EGRAG CRYPTO (@egragcrypto) October 11, 2025
The token has since recovered and is holding key support levels. XRP continues to trade above $2.00 as investors focus on institutional developments.
Nasdaq-listed company Reliance Global recently added XRP to its digital treasury. This marks a shift toward treating XRP as a strategic asset rather than a speculative token.
VivoPower also integrated XRP into its treasury system. The company launched XRPFi, a program combining enterprise finance with blockchain yield strategies on the XRP Ledger.
Ripple purchased prime brokerage firm Hidden Road for $1.25 billion. The acquisition allows Ripple to process post-trade operations on the XRP Ledger.
This move positions the token as infrastructure for international financial processes. The deal represents one of Ripple’s largest investments in traditional finance integration.
Ripple launched its RLUSD stablecoin in Africa through partnerships with three companies. Chipper Cash, VALR, and Yellow Card are facilitating cross-border remittances using the stablecoin.
These partnerships enable blockchain-based settlements for corporate and insurance transactions. The expansion targets regions where traditional banking infrastructure remains limited.
In the United Arab Emirates, Ripple received regulatory approval from the Dubai Financial Services Authority. The company became one of the first blockchain payment providers authorized in the Dubai International Financial Centre.
Ripple formed agreements with Zand Bank and fintech platform Mamo in the region. These partnerships strengthen the company’s presence in Middle Eastern financial markets.
According to XForceGlobal, XRP is following a Flat corrective pattern in its Elliott Wave cycle. The token broke out of a multi-year descending triangle formation.
$XRP
Still bullish on the macro.#XRP has chosen the Flat route. We still have this as the final bullish option, and is now within the confirmation stage. From a timing perspective, it's looking great.
This would be our last exhausted option. Below $0.60 would be very bearish. https://t.co/opAeWnOLkQ pic.twitter.com/y4HBn8OUfg
— XForceGlobal (@XForceGlobal) October 12, 2025
Previous market cycles saw XRP drop 78%, 67%, and 52% before establishing higher lows. Each crash was followed by recovery that maintained the longer-term upward structure.
The most critical support level sits at $0.60. A drop below this price would invalidate the bullish structure.
Near-term resistance exists between $3.30 and $3.50. If XRP breaks through these levels, medium-term targets point to $9.30.
The longer-term Elliott Wave count suggests potential prices between $27 and $34 if the pattern completes. These projections depend on the token maintaining current support levels and completing the expected wave structure.
XRP currently trades at $2.14 on some exchanges after testing the 161.8% Fibonacci extension level.
📈 Futures & Crypto Trader 🔍 Sharing charts, strategies, & mindset tips to help you level up 🚨 Not Financial Advice Follow on X @Pro_Trader_Edge
TLDR President Trump owns approximately $870 million in Bitcoin through his 41% stake in Trump…
The price of digital gold has rebounded following the decline on October 11. The drop was attributed to macroeconomic news rather than internal events in the crypto market, noted The Block analyst Presto Research’s Rick Maeda.
At the time of writing, Bitcoin’s price had risen by 3.2% over the past 24 hours to approximately $115,400, according to CoinGecko. Ethereum increased by 9% to around $4,190.
Maeda believes the crash was triggered by news of China’s export restrictions and the US’s retaliatory plans for 100% tariffs on tech imports.
According to the expert, the sell-off coincided with low liquidity over the weekend, which “caused forced liquidations worth billions of dollars.”
According to CoinGlass, on October 11, crypto platforms closed positions of more than 1.6 million traders amounting to $19.1 billion.
The largest liquidation event in crypto history.
In the past 24 hours, 1,618,240 traders were liquidated, with a total liquidation amount of $19.13 billion.
The actual total is likely much higher — #Binance only reports one liquidation order per second.… pic.twitter.com/tvMCILVgU0
— CoinGlass (@coinglass_com) October 10, 2025
Analysts are divided on the future prospects of the upward trend known as Uptober.
Kronos Research’s Chief Investment Officer Vincent Liu believes that risk appetite has returned and the trend “remains alive.” CoinW’s Chief Strategy Officer Nassar Achkar agrees, adding that traders are watching the US inflation report, the Fed meeting, and inflows into spot ETFs.
LVRG Research’s Director Nick Rak noted that the rebound was supported by on-chain data showing Ethereum accumulation by whales.
Maeda suggested that the trend has been affected, though it “has not derailed.” In his view, the record volume of liquidations could remain a “heavy burden” for market participants, who will now be more sensitive to news about US-China trade disputes.
As reported by The Kobeissi Letter, authors stated that the cryptocurrency crash will not have long-term fundamental consequences, attributing it to a combination of technical factors.
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In an unexpected turn of events, the U.S. government shutdown has plunged the cryptocurrency landscape into disarray. Investors are left in the lurch as a slew of crucial cryptocurrency exchange-traded fund (ETF) approvals come to a screeching halt. As the stalemate drags on week after week, the weight of uncertainty looms large, unsettling the very foundations of the crypto market. This predicament highlights a stark irony: the world of decentralized finance, which boldly promises autonomy and independence, remains shackled to convoluted centralized regulations.
The shutdown has dramatically hampered the approval process for more than 16 cryptocurrency ETFs, locking major players like Bitcoin, Litecoin, and Solana in a regulatory vacuum. The U.S. Securities and Exchange Commission (SEC), sidelined by political squabbles, stands unable to address essential filings, leaving the anticipated influx of institutional investments flickering like a candle in the wind.
Senior ETF Analyst Eric Balchunas likens this scenario to “a rain delay,” implying that while the pause is temporary, its consequences could ripple through the market in unpredictable ways. Both retail and institutional investors feel the pressure as they anxiously await a resolution. The pause disrupts flows of capital, forcing all to stand by as the clock winds down, leaving the air thick with tension.
At the heart of this ongoing crisis lies a profound political divide, with Republicans and Democrats seemingly locked in an unyielding standoff that has precipitated the current shutdown. Disagreements over fiscal policy have thrown a wrench in the works, stifling progress and clouding the path to clearer regulatory guidance for cryptocurrencies. Historically, such political impasses have led to spikes in market volatility, causing many to wonder just how long this stalemate might last and what it means for digital assets in the interim.
As the uncertainty stretches on, wild speculation swirls around the timeline for potential approvals. The stakes couldn’t be higher; the fate of numerous cryptocurrencies now seems tethered to the whims of a political system at a standstill.
Amid the uncertainty, a glimmer of hope flickers on the horizon. Analysts remain cautiously optimistic that, once the government reopens and the SEC gets back to business, we may witness an avalanche of ETF approvals that could revitalise the market. Nate Geraci, President of NovaDius Wealth Management, suggests that the resolution of this legislative deadlock may serve as a catalyst for new investment activity. With the market teetering on the brink of potential transformation, many are poised to seize fresh trading opportunities as soon as the proverbial green light shines.
There’s a growing sentiment that this rush of approvals could ignite an altcoin season, raising the profile of lesser-known cryptocurrencies vying for attention as new financial products hit the trading floor. This anticipation encapsulates a sense of urgency, urging institutional players to recalibrate their strategies in preparation for the inevitable regulatory thaw.
As the shutdown continues, traditional finance and cryptocurrency alike grapple with the fog of uncertainty cast by bureaucratic oversight. However, the crypto sector finds itself in a uniquely precarious position. Deeply entangled with institutional frameworks that require clarity, many crypto-native businesses are feeling the pinch as they grapple with the implications of prolonged regulatory delays.
In light of these challenges, Web3 startups are actively refining their strategies to weather the storm. By crafting contingency plans and innovative financial solutions, these enterprises are forging alternative paths to sustainability that are less reliant on governmental timelines. The imperative for adaptability has never been clearer, pushing firms to keep pace with a rapidly evolving landscape marked by disruptions.
The current U.S. government shutdown has laid bare the vulnerabilities of the cryptocurrency sector, casting a long shadow over investor sentiment. While a sense of cautious neutrality prevails, the allure of future ETF approvals continues to captivate market participants. This legislative gridlock serves as a stark reminder of the intricate ties between broader political dynamics and the fates of digital assets.
As the community braves this turbulent tableau, all eyes remain glued to the horizon, hoping for the reopening of regulatory channels — a pivotal moment that promises to unlock new opportunities and shape the evolution of the market. The complexity ahead is undeniable, but the prevailing hope is that clarity will emerge soon, heralding a bright new chapter in cryptocurrency investment. Until that moment arrives, the crypto sphere holds its breath, anticipating a return to stability that nurtures further innovation and growth.
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The U.S. government shutdown disrupts cryptocurrency ETF approvals, creating uncertainty for investors while political deadlock clouds regulatory clarity.
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